The inaugural event of the U.S.-Islamic World Forum was held in Doha, Qatar on January 10-12, 2004. The conference convened some 150 leaders in politics, business, academe, media, and civil society from the United States and 38 Muslim countries, with the goal of encouraging dialogue and improving relations between the United States and the Islamic world.

The 2005 U.S.-Islamic World Forum brought together leaders from politics, business, media, academia, and civil society from across the Islamic world for an annual dialogue with their American counterparts. The 2005 conference was held on April 10-12 in Doha, Qatar, and hosted more than 160 leaders from the United States and 35 Muslim countries.

The 2006 U.S.-Islamic World Forum was held February 18-20 in Doha, Qatar. A global leaders conference, the forum brought together over 180 American and Muslim world leaders from the realms of politics, business, media, academia, arts, science, and civil society. Thirty-eight countries were represented, with 23 sessions over the course of the forum, covering issues ranging from Iraq and the Danish cartoon controversy to development concerns and the role of artist as a public figure.